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9 Studies on the Effectiveness of the Picosecond Laser for Tattoo Removal

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In recent years, there have been some great advancements in tattoo removal technology. Gone are the days of having to apply a cream or actually getting the ink cut out of your skin, both of which never proved successful in the first place.

At present, the latest laser for tattoo removal is the Picosecond which our PicoSure machine boasts. This laser uses ultra-short pulses of energy to shatter the ink into tiny dust-like particles ready for natural removal via the immune system. These pulses are measured in picoseconds; which is one trillionth of a second.

But in order to find out whether this type of laser technology is truly effective in removing tattoos, various studies have taken place, such as the nine listed below.

1. Treatment of Tattoos with Picosecond laser pulses vs. Nanosecond Domain Pulses

*This was the first ever study on Picosecond laser pulses for tattoo removal, published in February 1998!

Method – 8 consenting patients received a total of 4 treatments at 4-week intervals with Picosecond laser pulses. The same number of patients received the same number of treatments at 4-week intervals with nanosecond domain pulses. All 16 patients completed the study and all patients had black tattoos.

Results – A panel of dermatologists not associated with the study were enlisted to compare photographs of each patient’s tattoos to compare lightness. Electron micrographs were also examined to check for electron density and size changes. It was established by the panel that in 12 of 16 tattoos, there was significant lightening in the picosecond-treated areas compared with those treated with nanosecond pulses. And in terms of electron density and size changes, similar changes were seen for both laser treatments.

Conclusion – Picosecond pulses are a more effective treatment than nanosecond pulses for black tattoos and in some cases, it is possible to clear tattoos with fluences of a lesser magnitude than with nanosecond domain pulses.

Click here to view the study.

2. Successful and Rapid Treatment of Blue and Green Tattoo Pigment With a Novel Picosecond Laser

Method – Treated 12 tattoos containing blue and/or green pigment with the picosecond 755-nm alexandrite laser.

Results – Tattoos demonstrated at least 75 per cent clearance of blue and green pigment after 1 or 2 treatments. More than two-thirds of these tattoos also approached closer to 100 per cent clearance.

Conclusion – This new technology is more effective in targeting blue and green pigment, resulting in quicker treatment with less injury to surrounding tissue.

Click here to view the study.

3. Treatment of Tattoos With a Picosecond Alexandrite Laser

Method – Used a picosecond laser on fifteen patients with tattoos and scheduled treatment approximately 6 ± 2 weeks apart. Took standard two-dimensional photographs at baseline before each treatment, and one month and 3 months after the last treatment.

Results – 12 patients completed the study and all of them obtained greater than 75 per cent clearance. Nine patients also obtained greater than 75 per cent clearance after 2-4 treatments, while all 12 said they were satisfied or extremely satisfied with the treatment.

Conclusion – The picosecond 755-nm alexandrite laser is a safe and very effective procedure for removing tattoo pigment.

Click here to view the study.

4. Treatment of Resistant Tattoos with Picosecond Alexandrite Laser

Method – Took 37 patients with six or more previous nanosecond laser treatments. Before and after images were evaluated by blind reviewers and graded on a quartile scale.

Results – Additional tattoo clearing was seen in 36 of 37 patients, while near complete clearing was observed in 15 of the 37. The mean number of treatments for 90 per cent reduction was just two.

Conclusion – Picosecond lasers may be effective when nanosecond lasers have reached a plateau and no further clearance can be completed.

Click here to view the study.

5. Clearance of yellow tattoo ink with a novel 532-nm picosecond laser

Method – Treatment took place at 6-8 week intervals on six subjects with multi-coloured tattoos that contained yellow pigment.

Results – One subject achieved complete clearance after one session, while the remaining five required 2-4 treatments to achieve over 75 per cent clearance. No scarring or textural skin changes were observed either.

Conclusion – First case series that demonstrates effective and consistent reduction of yellow tattoo ink using a laser with picosecond pulse duration.

Click here to view the study.

6. Safety and effectiveness of black tattoo clearance in a pig model after a single treatment with a novel 758 nm 500 picosecond laser: A pilot study

Method – Six weeks after carbon and iron oxide tattoos were placed on a pig, they were both treated with either a 758 nm 500 picosecond laser, a 755 nm 30-50 nanoseconds laser, or left untreated. After 4 weeks, clinical responses were evaluated by three dermatologists based on photographs, histopathologic findings were evaluated by a dermatopathologist, while electron microscopic findings were also analysed.

Results – After one treatment, picosecond pulses produced a greater degree of carbon tattoo clearance than nanosecond pulses. Neither treatment resulted in scarring, textural changes, or hypopigmentation.

Conclusion – The picosecond laser was more effective at carbon tattoo clearance after one session than a nanosecond laser emitting at a similar wavelength. Both lasers cleared carbon tattoos move effectively than iron oxide tattoos.

Click here to view the study.

7. A New Paradigm for Optimal Tattoo Removal Using Three Picosecond Laser Wavelengths

Method – Picosecond treatments with 755nm, 532nm and 1064nm performed at 1-2 month intervals on 44 subjects with 53 tattoos. Blinded evaluation was also performed at the end of the study.

Results – 31 tattoos with red, yellow, and/or orange pigments responded best to 532nm and achieved 75-100 per cent clearance after an average of 2 treatments. 17 tattoos with blue, purple, and/or green pigments responded best to 755nm, while 88 per cent of subjects achieved 75-100 per cent clearance after an average of 2 treatments. 7 tattoos with black ink responded equally to 755nm and 1064nm after 1-2 treatments.

Conclusion – The picosecond laser is a safe and efficient tool for tattoo removal, but requires multiple wavelengths. To clear most ink, a combination of 532nm and 755nm is needed, but 1064nm may be preferable for black ink and darker skin types.

Click here to view the study.

8. Treatment of Traumatic Tattoo Using Picosecond Alexandrite Laser

Method – Attempt to clear the untreated traumatic tattoo on the nose of a 62-year-old man using a 755nm picosecond laser.

Results – 6 weeks after treatment, the test spot showed near complete clearance. The reminder of the lesion was treated with the same settings and near complete clearance was achieved again.

Conclusion – The first safe and successful treatment of a traumatic tattoo rather than an ink-based tattoo using this class of device.

Click here to view the study.

9. Assessing the effectiveness of a Picosecond Nd:YAG laser to treat black, green, purple, blue, red and yellow ink

Method – 21 consenting subjects with 31 tattoos of varying design and colour were treated with Picosecond pulses. Subjects with black, blue, green, and purple inks were treated with a 1,064 nm wavelength while subjects with red and yellow inks were treated with the 532 nm wavelength. The treatments were administered at 6-10 week intervals.

Results – Photographs were taken before each treatment session of the subject’s tattoos and a 10-point scale was used to assess Picosecond’s effectiveness, with 0 being no clearance and 10 being complete clearance. The photographs were evaluated by three investigators with no input into the study whatsoever. In total, a score of 7.94 ± 0.09 corresponding to 79% removal was found on average. The clearance score was 92% on black tattoos, 65% on green, 78% on purple, 43% on blue, 80% on red and 85% on yellow.

Conclusion – Picosecond laser pulses are a safe and effective treatment for tattoo removal beyond black ink. Black and red pigment was removed effectively while yellow ink – which is traditionally one of the toughest to remove – saw an encouragingly high clearance rate.

Click here to view the study.

At Andrea Catton, we are lucky enough to have one of only five PicoSure lasers in the UK, which is a tattoo removal machine that uses picosecond pulses of energy. PicoSure is FDA approved, can achieve 75 per cent or greater clearance after one treatment and has a 95 per cent recommendation rate worldwide.

Andrea Catton

Andrea has over over 40 years experience delivering beauty and skin care treatments and has over 20 years laser experience. Regarded as the number one PicoSure laser technician in the UK, Andrea is trained and qualified to use Aculight HR IPL, Chromolite IPL, N-Lite laser, Ellipse, Episoft MD IPL, ADL Sapphire Nd:YAG, RevLite & PicoSure. Andrea is also a member of the British Institute & Association of Electrolysis, British Medical Laser Association and is fully qualified to teach IPL & laser hair removal.

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